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Using the eraser tool

The eraser tool allows you to remove pixels from a layer. Simply click and move your mouse around to erase things. By default, it removes only one pixel, but that can be changed its properties panel:

Eraser Properties

To change the size of the eraser tool:

Simply change the line thickness in the eraser tool's properties panel. The next time you erase, it will remove a square of that many pixels on each side.

See also

Changing tool properties
Setting a tool's pattern
Tools
Patterns